徐开寿，男，xksyi@126.com，医学博士、教授、博士/硕士研究生导师。现为国家儿童区域医疗中心、广州医科大学附属妇女儿童医疗中心（广州市妇女儿童医疗中心）儿科研究所所长、康复科主任、康复教研室主任。广东省首批杰出青年医学人才，广州市高层次卫生人才，加拿大英属哥伦比亚大学（UBC）附属儿童医院访问学者。从事儿童康复临床与科研工作20多年，多次前往加拿大、美国、德国、法国、以色列和新加坡等访问学习，南方医科大学神经病学博士、中山大学康复医学与理疗学硕士、上海体育学院体育保健康复学士。
主要研究方向及领域：儿童脑性瘫痪、肌性斜颈、语言认知障碍、运动障碍、吞咽障碍的基础与临床，以及儿童发育与康复评估工具、康复新技术的研发和产学研转化等。
学术任职：中华医学会儿科学分会康复学组副组长，中国康复医学会物理治疗专委会副主委，中国残疾人康复协会人工智能康复专委会副主委，广东省医学会社区康复学分会第四届委员会主委，广东省残协小儿脑瘫康复专委会主委, 《pediatric investigation》青年编委。
科研成果：主持国自然面上项目和省市级等科技项目21项，获国家专利5项、省部级科技奖3项及计算机软件著作权2项。以第一或通讯/共同通讯作者在Brain等国内外期刊发表论文70余篇（SCI收录26篇，单篇IF最高14.5），其中先天性肌性斜颈研究成果被国际临床实践指南引用。主持及参与制定国际、国家级指南/专家共识19项。主编专著6部。2014年建立中国内地首家“座椅银行”，2019年发起成立由80家单位组成的“小儿脑瘫专病管理联盟”。
部分相关论文及专著（*通讯作者，#并列第一作者）：
1. Li N#, Zhou P#, Tang H#, He L#, Fang X#, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl A, Gecz J, Han D*, Liu D*, Xu K*, Hu H*. In-depth analysis reveals complex molecular etiology in a cohort of idiopathic cerebral palsy. Brain. 2022, 145(1):119-141.
2. Liu L#, Wang Y#, He L#, Xu Y, Huang J, Peng T, Yang X, Pan J, Tang H*, Xu K*. Constraint-induced movement therapy promotes neural remodeling and functional reorganization by overcoming Nogo-A/NgR/RhoA/ROCK signals in hemiplegic cerebral palsy mice. Neurorehabil Neural Repair. 2021,35(2): 145-157.
3. Li J#, He L#, Tang H#, Peng T#, Long Y, Zeng P, Huang Y, Chen Z, Han M, Xu K*. Adverse events after different forms of botulinum neurotoxin A injections in children with cerebral palsy: An 8-year retrospective study. Dev Med Child Neurol.2023,65(1):86-93.
4. Sun C#, Guo R#, Ye X#, Tang S, Chen M, Zhou P, Yang M, Liao C, Li H, Lin B, Zang C, Qi Y, Han D, Sun Y, Li N, Zhu D*, Xu K*, Hu H*. Wybutosine hypomodification of tRNAphe activates HERVK and impairs neuronal differentiation. iScience. 2024;27(5):109748. doi: 10.1016/j.isci.2024.109748.
5. Tang H#, Pan J#, Xu Y#, Liu L, Yang X, Huang S, Peng T, Huang Y, Zhao Y, Fu C, Zhou H, Chen Z, Wang W, He L, Xu K*. Constraint Therapy Promotes Motor Cortex Remodeling and Functional Improvement by Regulating c-Jun/miR-182-5p/Nogo-A Signals in Hemiplegic Cerebral Palsy Mice. Ann Anat. 2023,250:152136.
6. Hu H*, Xu K*. Reply: Is it time to rename hereditary cases of cerebral palsy? Brain. 2022, 145(10):e84-e85.
7. Tang H#, Peng T#, Yang X#, Liu L, Xu Y, Zhao Y, Huang S, Fu C, Huang Y, Zhou H, Li J, He L, Wang W, Niu H, Xu K*. Plasma Metabolomic Changes in Children with Cerebral Palsy Exposed to Botulinum Neurotoxin. J Proteome Res. 2022, 21(3):671-682.
8. Fu C#, Tang H#, Liu L#, Huang Y, Zhou H, Huang S, Peng T, Zeng P, Xu Y, Yang X, He L*, Xu K*. Constraint-induced movement therapy promotes myelin remodeling and motor function by mediating Sox2/Fyn signals in rats with hemiplegic cerebral palsy. Phys Ther. 2024 May 1;104(5):pzae011. doi: 10.1093/ptj/pzae011.
9. Zhao Y#, He L#, Peng T#, Liu L#, Zhou H, Xu Y, Yang X, Huang Y, Chen Z, Xu Y, Li J, Hou X*, Tang H*, Xu K*. Nutritional status and function after high-calorie formula versus Chinese food intervention in undernourished children with cerebral palsy. Front Nutr. 2022, 9: 960763.
10. Zhao Y#, Tang H#, Peng T#, Li J, Liu L, Fu C, Zhou H, Huang S, Huang Y, Zeng P, Wang W, He L*, Xu K*, and Research Group. The relationship between nutritional status and severity of cerebral palsy: a multicenter cross-sectional study. J Rehabil Med. 2023, 55: jrm00367.
11. Huang S#, Liu L#, Huang Y, Fu C, Peng T, Yang X, Zhou H, Zhao Y, Xu Y, Zeng X, Zeng P, Tang H, He L*, Xu K*. Potential optimized route for mesenchymal stem cell transplantation in a rat model of cerebral palsy. Exp Cell Res. 2023,430(2):113734.
12. Huang Y#, Chen Z#, Xu Y#, Liu L, Tang H, He L, Zhang J, Zhou H, Xu Y, Zhao J, Wu L, Xu K*. Proteomic changes of the bilateral M1 and spinal cord in hemiplegic cerebral palsy mouse: Effects of constraint-induced movement therapy. Behav Brain Res. 2023,452:114583.
13. Yang X#, Tang H#, He L#, Peng T#, Li J, Zhang J, Liu L, Zhou H, Chen Z, Zhao J, Zhang Y, Zhong M, Han M, Zhang M, Niu H, Xu K*. Proteomic changes of botulinum neurotoxin injection on muscle growth in children with spastic cerebral palsy. Proteom Clin Appl. 2024 Mar 8:e2300070. doi: 10.1002/prca.202300070. Online ahead of print.
14. Wang Y#, He L#, Huang J#, Li J, Liu L, Xu Y, Peng T, Yang X, Zhao Y, Fu C, Huang S, Tang H*, Xu K*. Association of Nogo-A gene polymorphisms with cerebral palsy in Southern China: a case-control study. Dev Neurosci. 2023,45(1):8-18.
15. Peng T#, Zhao Y#, Fu C, Huang S, Zhou H, Li J, Tang H, He L, Xu K*. A Study of Validity and Reliability for Subjective Global Nutritional Assessment in Outpatient Children with Cerebral Palsy. Nutr Neurosci. 2022, 25(12):2570-2576.
16. He W#, Huang Y#, He L#, Liu L, Zeng P, Qiu H, Wang X, Zhou H, Chen Z, Xu Y, Zhao J, Wang W, Tang H*, Xu K*. Safety and effects of transcranial direct current stimulation on hand function in preschool children with hemiplegic cerebral palsy: a pilot study. Front Behav Neurosci. 2022,16:925122.
17. Zhang F, Li F, Chen F, Huang J, Luo Q, Du X, Zhou J, Gu W, Xu K*. Novel variant expands the clinical spectrum of CUX2-associated developmental and epileptic encephalopathies. Front Genet. 2022, 13: 808181.
18. Wu Q#, Peng T#, Liu L, Zeng P, Xu Y, Yang X, Zhao Y, Fu C, Huang S, Huang Y, Zhou H, Liu Y, Tang H, He L*, Xu K*. The effect of constraint-induced movement therapy combined with repetitive transcranial magnetic stimulation on hand function in preschool children with unilateral cerebral palsy: a randomized controlled preliminary study. Front Behav Neurosci. 2022, 16: 876657.
19. Tang H#, Xu Y#, Liu L, He L, Huang J, Pan J, He W, Wang Y, Yang X, Hou X*, Xu K*. Nogo-A/S1PR2 signaling pathway inactivation decreases microvascular damage and enhances microvascular regeneration in PDMCI mice. Neuroscience. 2020, 449:21-34.
20. Zhao X, Chen T, Fu B, Fu Z, Xu K*, Zhou W*. Mutations obstructing ATP's emplacement in KIF2A nucleotide-binding pocket causes parenchymal malformations, motor developmental delay, with intellectual disability. Mol Genet Genomic Med. 2023,11(10):e2225.
21. Chen Y#, He L#, Xu K*, Li J, Guan B, Tang H. Comparison of calf muscle architecture between children with spastic cerebral palsy and typically developing children. PLoS ONE. 2018, 13(1): e0190642.
22. He L, Yan X, Li J, Guan B, Ma L, Chen Y, Mai J*, Xu K*. Comparison of 2 Dosages of Stretching Treatment in Infants with Congenital Muscular Torticollis: A Randomized Trial. Am J Phys Med Rehabil. 2017, 96(5):333-340. (此成果被国际临床实践指南引用及推荐，见Pediatr Phys Ther 2018,30:240-290）
23. Xu K*, He L，Mai J, Yan X, Chen Y. Muscle recruitment and coordination following constraint-induced movement therapy with electrical stimulation on children with hemiplegic cerebral palsy: a randomized controlled trial. PLoS ONE. 2015,10(10):e0138608.
24. Xu K*, Mai J, He l, Yan X, Chen Y. Surface electromyography of wrist flexors and extensors in children with hemiplegic cerebral palsy. PM&R. 2015, 7(3): 270-275.
25. Xu K, Wang L*, Mai J, He L. Efficacy of constraint-induced movement therapy and electrical stimulation on hand function of children with hemiplegic cerebral palsy: A controlled clinical trial. Disabil Rehabil. 2012, 34(4):337-346.
26. Xu K, Yan T*, Mai J. A randomized controlled trial to compare two botulinum toxin injection techniques on the functional improvement of the leg of children with cerebral palsy. Clin Rehabil. 2009,23(9):800-811.
27. He Y#, Cai S#, Peng T, Qiao Y, Wu N, Xu K*. Machine learning enables update to pediatric neurorehabilitation. Pediatr Investig. 2024,00:1-3.
28. Hou X#, Qiu H#, Liu L#, Li Y, He L, Li J, Tang H, Xu K*. Reliability and validity of the East Asian children's version of mini-MACS in children with cerebral palsy. Front Rehabil Sci. 2022,3:997221.
29. Hong L#, Xu K#, Zhu D#, Sun L, Dipasquale V, Romano C*. Nutritional Management of Children with Neurological Impairment in China: Current Status and Future Directions. JPGN Reports. 2022. 3(1):e154.
30. Sun C#, Zhou P#, Yuan S#, Guo R, Zhang Z, Xu Q, Han D, He L, Tang H, Xu K, Hu H, Li N*. Generation of an induced pluripotent stem cell line SYSUi-004-A from a child of microcephaly with TYW1 mutations. Stem Cell Res. 2020, 45: 101783.
31. Darrah J, O’Donnell M, Story M, Lam J, Wickenheiser D, Xu K, Jin X. Designing a clinical framework to guide gross motor intervention decisions for infants and young children with hypotonia. Infants Young Child. 2013, 26(3): 225-234.
32. Qiu H#, Zhang H#, Zhang J#, Kuo F#, Huysentruyt K, Smith C, Bhutada A, Xiao N*, Xu K*, Expert panel, the Subspecialty Group of Rehabilitation of Chinese Pediatric Society, Chinese Medical Association. International consensus on early rehabilitation and nutritional management for infants at high risk of neurological impairments. Pediatr Investig. 2024;00:1-12.https://doi.org/10.1002/ped4.12426.
33. 中华医学会儿科学分会康复学组（通讯作者：徐开寿*，肖农*,黄真*）. 儿童脑性瘫痪运动障碍的康复建议. 中华儿科杂志，2020，58(2):91-95.
34. 中华医学会儿科学分会康复学组（通讯作者：徐开寿*，肖农*）. 儿童脑性瘫痪肉毒毒素治疗专家共识. 中华儿科杂志，2018，56(7):484-488.
35. 中华医学会儿科学分会康复学组（通讯作者：徐开寿*）. 儿童脑性瘫痪吞咽障碍的康复建议. 中华儿科杂志，2022，60(3)：192-196.
36. 中华医学会儿科学分会康复学组，中国康复医学会物理治疗专委会（通讯作者：徐开寿*，肖农*）. 儿童脑性瘫痪经颅磁刺激治疗专家共识.中华实用儿科临床杂志，2022，37(5):333-337.
37. 中华医学会儿科学分会康复学组，中国康复医学会物理治疗专委会（通讯作者：徐开寿*，肖农*）.脊髓性肌萎缩症康复管理专家共识.中华儿科杂志,2022,60(9):883-887.
38. 中华医学会儿科学分会康复学组，中国康复医学会物理治疗专委会（通讯作者：肖农*，徐开寿*）. 中国神经重症儿童的亚重症康复管理专家共识.中华危重病急救医学，2021，33(10):1165-1174.
39. 中华医学会儿科学分会康复学组（通讯作者：徐开寿*，肖农*，刘芸*）.儿童康复相关发育性疾病的命名现状与建议.中国全科医学，2022，25(8): 899-904.8.
40. 中华医学会儿科学分会康复学组（通讯作者：肖农*，徐开寿*，胡继红*）. 儿童脑性瘫痪疼痛管理专家共识. 中国实用儿科杂志，2020，35(9)：673-677.
41. 徐开寿，肖农主编. 康复治疗师临床工作指南—儿童疾患物理治疗技术. 724千字. 北京：人民卫生出版社，2019.4. ISBN 978-7-117-27447-0.
42. 徐开寿 主编.儿科物理治疗学（第二版）. 979千字. 广州：中山大学出版社，2023.12. ISBN 978-7-306-07864-3.
43. 徐开寿主编.儿科物理治疗学. 630千字. 广州：中山大学出版社，2016.7. ISBN 978-7-306-05724-2.
44. 徐开寿，何璐主编.儿童发育迟缓家庭康复.277千字.北京：电子工业出版社，2023.06. ISBN 978-7-121-45706-7.
45. 徐开寿主编.儿童发育迟缓居家康复指导.346千字.北京：电子工业出版社，2019.12. ISBN 978-7-121-35549-3.
46. 肖农，徐开寿主编.儿童重症康复学. 874千字. 北京：人民卫生出版社，2019.10.ISBN 978-7-117-28870-5.
47. 徐开寿 副主编. 儿童康复诊疗规范. 557千字. 北京：人民卫生出版社，2023.03. ISBN 978-7-117-34014-4.